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随着系统科学发展,越来越多的研究对合成添加剂安全性提出质疑。
《自然》今天刊登了一篇合成甜味剂对人体影响的研究结果,如果研究获得更多检验,这将导致合成食品添加剂受到致命打击,而天然添加剂应用将更快普及。
天然甜味剂,比如中国传统常用的甘草、甜菊叶、罗汉果等等。
英文摘要:
《Non-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota. These NAS-mediated deleterious metabolic effects are abrogated by antibiotic treatment, and are fully transferrable to germ-free mice upon faecal transplantation of microbiota configurations from NAS-consuming mice, or of microbiota anaerobically incubated in the presence of NAS. We identify NAS-altered microbial metabolic pathways that are linked to host susceptibility to metabolic disease, and demonstrate similar NAS-induced dysbiosis and glucose intolerance in healthy human subjects. Collectively, our results link NAS consumption, dysbiosis and metabolic abnormalities, thereby calling for a reassessment of massive NAS usage.》
中文摘要:
我们使用不含热量的人造甜味剂已经超过一个世纪了。今天食品工业将它们用在食品中的数量越来越大,同时它们也被推荐用于减肥和供患葡萄糖耐受不良及2-型糖尿病的人使用。Eran Elinav及同事发现,三种最常用的不含热量的人造甜味剂(糖精、三氯蔗糖和阿斯巴甜)的消耗,会直接诱发小鼠产生肥胖和葡萄糖耐受不良倾向。这些效应由小肠微生物群的组成和功能的变化调节,有害代谢效应可以通过“粪便移植”转移给无菌小鼠,并可通过抗生素治疗被消除。作者显示,人造甜味剂能诱发健康人士发生菌群失调和葡萄糖耐受不良。他们提出,可能有必要制定专门针对个体以及针对肠道微生物群变化的新的营养策略。
中文摘要:http://www.natureasia.com/zh-cn/nature/highlights/56670 |
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